OralDNA can detect various oral pathogens that may threaten a patient's oral and systemic health. Many common pathogens that cause gum disease can also heighten one's risk of other systemic conditions. OralDNA diagnostic testing can help determine if patients were bone with specific genetic markers associated with increased inflammation, which is frequently linked with such conditions. It can often also determine the root cause of bad breath, dental decay, and tooth loss.

Such analysis is achieved by analyzing saliva samples for specific biomarkers. Biomarkers are an essential component of one's DNA. However, they are also found in antibodies, microbes, RNA, lipids, metabolites, and proteins. If these biomarkers are altered in action, concentration, function, or structure, the body may experience an onset, progression, or regression of a particular disorder or its immune response. Consequently, biomarkers are a critical tool in detecting, assessing, diagnosing, treating, and monitoring disease.